Automated NGS Library Preparation for High-Throughput Genomics

Advancing NGS Library Preparation Through Intelligent Automation

Next-generation sequencing (NGS) drives advances in translational research, precision oncology, and molecular diagnostics. However, library preparation remains one of the most labour-intensive and variability-sensitive stages of the workflow. Hamilton automation converts this bottleneck into a scalable, reproducible, and fully traceable process.

Hamilton’s automated liquid handling platforms support high-throughput genomic workflows while safeguarding data quality. By minimising manual intervention and reducing hands-on time, laboratories achieve consistent performance across large sample cohorts.

The Automated Yeast Cultivation and Long-Read RNA-Seq Sample Preparation on a Hamilton Microlab STAR integrated with bioREACTOR 48 DS demonstrates seamless integration of upstream cultivation and downstream RNA library preparation—enhancing experimental consistency and enabling reliable long-read sequencing.
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automated yeast cultivation and long read rna seq-sample-prep on microlab star integrated with bioreactor 48 ds

In clinical settings, the workflow described in Whole Genome and Transcriptome Analysis for Leukemia Diagnostics highlights how automation supports comprehensive genomic profiling with high reproducibility and improved traceability for sensitive samples.
Explore the application note:
whole genome and transcriptome analysis for leukemia diagnostics

For kit-based RNA workflows, the Watchmaker RNA Library Prep Kit on Microlab NGS STAR showcases consistent yield and fragment quality while reducing operator variability.
Details available at:
watchmaker rna library prep kit on microlab ngs star

By combining precise liquid handling, barcode verification, and integrated on-deck technologies, Hamilton enables confident scaling of library preparation—from research studies to clinical-scale projects.

Talk to Our Hamilton Experts About Your NGS Workflow at Booth C1.